Karen Kirkpatrick was diagnosed with lupus after five doctors dismissed her. She's since run 28 half marathons and the Disney World Marathon, and she's making her final three halves count.

Austin TV meteorologist Chikage Windler chased tornadoes in college and finally broke four hours in her 16th marathon. She also ran quietly through a breast cancer diagnosis.

Diagnosed with Parkinson's disease at 59, Steve Gilbert found Rock Steady Boxing, went back to running, and at 80 just finished his second Boston Marathon with a Boston PR.

Jess and JJ Jones are fresh off the Boston Marathon, parents of three, Ironman finishers, and about to open Main Street Running Collective in Hamilton, Ohio.

Dennis Mullen has run under three hours and qualified for Boston three times, yet he's never run it. We recorded on Marathon Monday and talked about cutoffs, a herniated disc and what the marathon owes us.

New York coach Noa Besner went from a 5:32 first marathon to a 3:26, ran races from Tokyo to the Arctic Circle, and now leads small-group race trips for runners of every pace.

Mike Vollmer has finished every Indy Mini since the first one in 1977, when entry cost $5. He's also the reason there are chocolate chip cookies at the finish line.

Keegan Kok lost 50 pounds, broke his leg on a playground, then ran his first 5K at 41. Four Chicago Marathons later, he coaches, co-founded a run club and won the Shamrock Shuffle mile.

Tammy Mirante qualified for Boston twice, then withdrew her application and decided to just run longer. Now she's one of the first women in Indiana to run 100 miles at a backyard ultra.

Doctors told Sally Hed Dahlquist she would be lucky to reach 15. She has now run 178 marathons, finished all 50 states and beaten every cutoff at Tokyo.

When Ryan Busby moved to Zionsville, he couldn't find a run club, so he helped start one. Less than a year later, the Zionsville Run Club is a nonprofit with its own Fourth of July 5K.

Angela Kumar is one of the first four women to run 100 miles at an Indiana backyard ultra. We talk twins, IVF, Boston, Prairie on Fire, and holding on to the joy of running.

For my 150th episode, Rob Perez, the creator who ran a mile for every day of the government shutdown, tells me why he stayed by my side for all 26.2 miles of the Marine Corps Marathon.

As a teenager, Carly Trulock Quinn was told to quit running after a sacrum fracture and a RED-S diagnosis. Now she runs 100Ks and is chasing $150,000 for Blood Cancer United.

Attorney Quincy Sauer's mom signed her up for the Indy Mini after a breakup in 2006. Twenty Minis later, she's a half Ironman, an open water swimmer, a new scuba diver and a stand-up comedy student.

Gretchen Hercamp had two brain surgeries in less than two years to remove a pituitary tumor. In between and after, she ran three marathons, a 50K and 1,000 miles in 2025.

Bob Roudebush was smoking a pack a day when he started run-walking on a YMCA treadmill in 2007. Now he runs 100-milers, and he once ran his fastest half marathon alongside David Goggins.

Shannon Spencer is a grandma, breast cancer survivor, skydiver, CrossFitter and marathoner who pushes for Ainsley's Angels and created a 48-mile fundraiser run in Kokomo.

Anthony Bruns shattered his kneecap at 32 and was told he'd never run again. At 46 he has run 2:23 at Boston, holds Colorado age group records, and still won't take a gel.

Sean Conlon has run at least 3.3 miles every day since August 2019, even through a broken toe. Next up: a 5K in all 50 states in 50 days.